Charge Measuring Electronics in Medical Applications
Low-noise current and charge sensing circuits are pivotal in a large variety of biomedical instruments, spanning from electrochemical biosensors to photodetectors for visibile and gamma radiation. In this tutorial, the common design challenges and guidelines will be discussed, with special focus on front-end CMOS ASICs. Applicative examples will focus on diagnostics, both from the (apparently opposite) perspectives of nano-biosensors, leveraging molecular affinity (miniaturized and integrated with lab-on-chip microfluidics), as well as hospital-based scanners for medical imaging. Advances and technical solutions to achieve compatibility of sensitive detection circuits with large magnetic fields enabling multi-modal medical imaging and diagnostics will be presented.